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Author: Dr Paul Langely

Latest Working Papers 

Methods to support Health Equity Evaluations: ICER and Non-evaluable Modeled claims versus Rasch Modelled Needs Fulfilment

April 1, 2023April 1, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

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Latest Working Papers 

Value Claims, Fundamental Measurement and The Patient Voice In Oncology: A Systemic Failure

March 16, 2023March 16, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

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Latest Working Papers 

Rejecting Pseudoscience: Imaginary Cost-Utility Claims Created By The Reference Case Simulation Modelling Of The National Insitute For Health And Care Excellence (NICE)

March 16, 2023March 16, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

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Latest Working Papers 

Post-Menopausal Quality Of Life Claims: Overlooking The Requirements of Normal Science and Fundamental Measurement In Icer’s Cost-Effectiveness Assessment Of Fezolinetant For Moderate To Severe Vasomotor Symptoms

March 16, 2023March 16, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

Read more
Latest Working Papers 

Rejecting Multiattribute Scores: Fundamental measurement and the generic EQ-Health and Wellbeing (EQ-HWB) instrument

January 31, 2023January 31, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

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Latest Working Papers 

Nonsense on Stilts: Fundamental Measurement and the Generic EQ-Health and Wellbeing (EQ-HWB) Instrument

January 12, 2023January 12, 2023 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

Read more
Latest Working Papers 

A Continuing Disaster: The EQ-Health and Wellbeing (EQ-HWB) Instrument

December 27, 2022December 28, 2022 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

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Latest Working Papers 

After the QALY? Failing to recognize  Rasch Measurement in proposing  the EQ-Health and Wellbeing (EQ-HWB) instrument as an interval scale to support therapy response claims and  QALYS

December 24, 2022December 25, 2022 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

Read more
Latest Working Papers 

Evaluating Disease Specific Patient Reported Outcomes Measures for Rasch Interval Score Application

November 13, 2022December 24, 2022 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

Read more
Latest Working Papers 

Post-Menopausal Quality of Life Claims: Overlooking the requirements of fundamental measurement in ICER’s cost-effectiveness assessment of fezolinetant for moderate to severe vasomotor symptoms 

October 17, 2022October 17, 2022 Dr Paul Langely

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, Minneapolis, MN The Maimon Working Papers are free to download (in PDF format) at the bottom of the page.

Read more
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  • Assumptions and Models
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  • The Mystical Viral QALY
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Latest Publications

Langley PC. Nothing to Cheer About: Endorsing  Imaginary Economic Evaluations and Value Claims with CHEERS 22 [version 1; peer review: awaiting peer review]

Abstract

One of the more unfortunate features of health technology assessment is the tenacity with which leaders in the field and organizations such as the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the Institute for Clinical and Economic Review (ICER) cling to an evaluation framework that fails to meet the standards of normal science.

A Critical Examination of Simulation Pricing and Access Recommendations for Atopic Dermatitis

Paul C. Langley, Ph.D., Adjunct Professor College of Pharmacy, University of Minnesota, MN

Abstract

It has been demonstrated conclusively that value and utility preference scores have only ordinal properties. That means, as has been pointed out on numerous occasions, that quality adjusted life year (QALY) is a mathematically impossible construct. Continue here.

A Critical Examination for the Pricing of Eculizumab and Efgartigimod in Myasthenia Gravis

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, MN

ABSTRACT

The purpose of this commentary is to focus on the downside of assumption-driven simulation modeling, the potential creation of a multitude of competing models, the mathematically impossible quality adjusted life year (QALY) and the failure to observe the axioms of fundamental measurement in mapping ordinal EQ-5D-5L preferences from the ordinal Quantitative Myasthenia Gravis Continue Here

Abandoning Eugenics and the QALY

Paul C. Langley, Ph.D., Adjunct Professor, College of Pharmacy, University of Minnesota, MN

ABSTRACT

Should decision making in health care, notably in respect of the allocation of resources between individuals and disease states, rest on notions of the burden of disease and denial of care as assessed by societal evaluations or on the extent to which the need of patients and caregivers is fulfilled. Continue here.

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